Orofacial antinociceptive activity of (S)-(-)-perillyl alcohol in mice: a randomized, controlled and triple-blind study.

@article{TomazMorais2017OrofacialAA,
  title={Orofacial antinociceptive activity of (S)-(-)-perillyl alcohol in mice: a randomized, controlled and triple-blind study.},
  author={James Felipe Tomaz-Morais and Renan Marinho Braga and Frederico Barbosa de Sousa and Dami{\~a}o Pergentino de Sousa and L.C. deM. Pordeus and Reinaldo N{\'o}brega de Almeida and Ricardo Dias de Castro},
  journal={International journal of oral and maxillofacial surgery},
  year={2017},
  volume={46 5},
  pages={
          662-667
        }
}
This study investigated the antinociceptive effects of (S)-(-)-perillyl alcohol (PA) on orofacial nociception in Swiss male mice using formalin-, capsaicin-, and glutamate-induced pain tests. For each test, eight animals per group were pre-treated intraperitoneally by a blinded investigator with PA (50 or 75mg/kg), morphine, or vehicle (saline+0.2% Tween 80). The treatment was performed before the induction of orofacial nociception by injecting formalin, capsaicin, or glutamate solution into… Expand
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