Orofacial antinociceptive activity of (S)-(-)-perillyl alcohol in mice: a randomized, controlled and triple-blind study.

  title={Orofacial antinociceptive activity of (S)-(-)-perillyl alcohol in mice: a randomized, controlled and triple-blind study.},
  author={James Felipe Tomaz-Morais and Renan Marinho Braga and Frederico Barbosa de Sousa and Dami{\~a}o Pergentino de Sousa and L.C. deM. Pordeus and Reinaldo N{\'o}brega de Almeida and Ricardo Dias de Castro},
  journal={International journal of oral and maxillofacial surgery},
  volume={46 5},
This study investigated the antinociceptive effects of (S)-(-)-perillyl alcohol (PA) on orofacial nociception in Swiss male mice using formalin-, capsaicin-, and glutamate-induced pain tests. For each test, eight animals per group were pre-treated intraperitoneally by a blinded investigator with PA (50 or 75mg/kg), morphine, or vehicle (saline+0.2% Tween 80). The treatment was performed before the induction of orofacial nociception by injecting formalin, capsaicin, or glutamate solution into… Expand
7 Citations
Natural products for orofacial nociception in pre-clinical studies: A systematic review.
These results indicate that NPs are effective in treating experimental orofacial nociception and highlight some of these NPs, mainly terpenes, suggesting their potential for translational research. Expand
Limonene, a food additive, and its active metabolite perillyl alcohol improve regeneration and attenuate neuropathic pain after peripheral nerve injury: Evidence for IL-1β, TNF-α, GAP, NGF and ERK involvement.
Both substances, LIM and POH, improved the regeneration process and sensory and motor function recovery in the PNI model in mice by mitigating the inflammatory reactions and up-regulating the neurotrophic process. Expand
(-)-cis-Carveol, a Natural Compound, Improves β-Amyloid-Peptide 1-42-Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus
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Perillyl alcohol has antibacterial effects and reduces ROS production in macrophages
The POH has antibacterial activity against periodontal pathogens and reduced proliferation of murine macrophages without significant cytotoxicity at concentrations up to 100 μM. Expand
Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus.
  • T. Nuutinen
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 2018
Terpenes' medicinal properties are supported by numerous in vitro, animal and clinical trials and show anti-inflammatory, antioxidant, analgesic, anticonvulsive, antidepressant, anxiolytic, anticancer, antitumor, neuroprotective, anti-mutagenic,Anti-allergic, antibiotic and anti-diabetic attributes, among others. Expand
Objectives : To evaluate the prevalence of dental erosion in schoolchildren 05-15 years of the medium-sized city in northeastern Brazil and compare the reproducibility and performance of two indicesExpand
A Toolbox for Diverse Oxyfunctionalisation of Monoterpenes
A scalable pipeline is presented that applies the methodology of synthetic biology itself to bootstrap the creation of a comprehensive enzyme library for the controlled oxyfunctionalisation of terpene scaffolds with a wide range of activities and selectivities towards several monoterpenes. Expand


Antinociceptive effects of citronellal in formalin-, capsaicin-, and glutamate-induced orofacial nociception in rodents and its action on nerve excitability.
Pretreatment with CTL was effective in reducing nociceptive face-rubbing behavior in both phases of the formalin test, which was also naloxone-sensitive. Expand
Citronellol Reduces Orofacial Nociceptive Behaviour in Mice – Evidence of Involvement of Retrosplenial Cortex and Periaqueductal Grey Areas
Together, the results provide first‐time evidence that this monoterpene attenuates orofacial pain at least, in part, through an activation of CNS areas, mainly retrosplenial cortex and periaqueductal grey. Expand
Antinociceptive activity of buprenorphine and lumiracoxib in the rat orofacial formalin test: a combination analysis study.
An unexpected difference between the theoretical and experimental ED(50), suggesting synergism in the first phase as well is found, suggesting synergistic interaction in the second phase of antinociceptive activity of analgesics and their combinations. Expand
Orofacial Analgesic-Like Activity of Carvacrol in Rodents
The results suggest that CARV might represent an important tool for the treatment of orofacial pain and showed that the action of CARV on the central nervous system (CNS) did not affect these results, since this compound did not exert a significant CNS-depressant effect. Expand
The orofacial formalin test in the mouse: a behavioral model for studying physiology and modulation of trigeminal nociception.
The presented mouse orofacial formalin test appears to be a reliable model for studying the behavioral encoding of the intensity of nociceptive oroFacial stimulation and the counter-irritation phenomenon and for testing analgesic drugs. Expand
The orofacial capsaicin test in rats: effects of different capsaicin concentrations and morphine
The orofacial capsaicin test appears to be a valid and reliable method for studying trigeminal pain mechanisms and testing analgesic drugs and the results of the present study also support the clinical use of peripheral opioid administration for the treatment of oroFacial painful conditions. Expand
Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw
This study characterizes the receptor subtypes and investigates some of the mechanisms by which glutamate, injected intraplantarly (i.pl.) into the mouse paw, produces nociception and paw oedema.Expand
The orofacial formalin test
The orofacial formalin test can then be considered as a reliable way of producing and quantifying nociception in the trigeminal region of the rat. Expand
Peripheral substance P and neurokinin-1 receptors have a role in inflammatory and neuropathic orofacial pain models
The results demonstrate that the peripheral SP/NK1 system participates in the heat hyperalgesia associated with inflammation or nerve injury and in the persistent pain evoked by formalin in the orofacial region. Expand
Application of the formalin test to the study of orofacial pain in the rat
The results indicate that this orofacial formalin test is a valid technique for the study of oroFacial pain. Expand