Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei

@inproceedings{Macdo2017OrnithineUA,
  title={Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei},
  author={Juan P. Mac{\^e}do and Rachel B Currier and Corina Wirdnam and David Horn and Sam Alsford and Doris Rentsch},
  booktitle={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2017}
}
Trypanosoma brucei, protozoan parasites that cause human African trypanosomiasis (HAT), depend on ornithine uptake and metabolism by ornithine decarboxylase (ODC) for survival. Indeed, ODC is the target of the WHO "essential medicine" eflornithine, which is antagonistic to another anti-HAT drug, suramin. Thus, ornithine uptake has important consequences in T. brucei, but the transporters have not been identified. We describe these amino acid transporters (AATs). In a heterologous expression… CONTINUE READING