Ornithine transcarbamylase downregulation is associated with poor prognosis in hepatocellular carcinoma

  title={Ornithine transcarbamylase downregulation is associated with poor prognosis in hepatocellular carcinoma},
  author={L. He and Xuefei Cai and Sheng-tao Cheng and Hong-zhong Zhou and Z. Zhang and J. Ren and F. Ren and Qiu-xia Yang and N. Tao and J. Chen},
  journal={Oncology Letters},
  pages={5030 - 5038}
  • L. He, Xuefei Cai, +7 authors J. Chen
  • Published 2019
  • Medicine
  • Oncology Letters
  • Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-associated mortalities worldwide. The role of ornithine transcarbamylase (OTC) in HCC remains unclear. In the present study, the expression of OTC in HCC was analyzed based on datasets from the Gene Expression Omnibus database of the National Center for Biotechnology Information and further confirmed by immunohistochemistry, western blotting analysis and reverse transcription-quantitative polymerase chain reaction assays on… CONTINUE READING


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