Ornithine decarboxylase in rat skin: 2. Differential response to hair plucking and a tumor promoter.

Abstract

Ornithine decarboxylase (OCD; EC 4.1.1.17) activity is induced in dorsal rat skin by either application of the tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate (TPA) or by hair plucking. In TPA-treated rat skin, ODC activity does not rise above controls until 3 hr posttreatment. Following a peak at 4 hr, ODC activity declines until it reaches control… (More)

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