Ornithine decarboxylase- and ras-induced cell transformations: reversal by protein tyrosine kinase inhibitors and role of pp130CAS.

@article{Auvinen1995OrnithineDA,
  title={Ornithine decarboxylase- and ras-induced cell transformations: reversal by protein tyrosine kinase inhibitors and role of pp130CAS.},
  author={Merja Auvinen and Aino Paasinen-Sohns and Hirokazu Hirai and Leif C Andersson and Erkki H{\"o}ltt{\"a}},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 12},
  pages={6513-25}
}
We have found that overexpression of human ornithine decarboxylase (ODC) induces cell transformation in NIH 3T3 and Rat-1 cells (M. Auvinen, A. Paasinen, L. C. Andersson, and E. Hölttä, Nature (London) 360:355-358, 1992). The ODC-transformed cells display increased levels of tyrosine phosphorylation, in particular of a cluster of 130-kDa proteins. Here we show that one of the proteins with enhanced levels of tyrosine phosphorylation in ODC-overexpressing cells is the previously described p130… CONTINUE READING

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