Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses.

@article{Singh2018OrnithineDI,
  title={Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses.},
  author={Kshipra Singh and Lori A Coburn and Mohammad Asim and Daniel P Barry and Margaret M. Allaman and Chanjuan Shi and M. Kay Washington and Paula B. Luis and Claus Schneider and A. G. Izaguirre Delgado and M Blanca Piazuelo and John L. Cleveland and Alain P Gobert and Keith T Wilson},
  journal={Cancer research},
  year={2018},
  volume={78 15},
  pages={
          4303-4315
        }
}
Ornithine decarboxylase (ODC) is the rate-limiting enzyme for polyamine biosynthesis and restricts M1 macrophage activation in gastrointestinal (GI) infections. However, the role of macrophage ODC in colonic epithelial-driven inflammation is unknown. Here, we investigate cell-specific effects of ODC in colitis and colitis-associated carcinogenesis (CAC). Human colonic macrophages expressed increased ODC levels in active ulcerative colitis and Crohn's disease, colitis-associated dysplasia, and… CONTINUE READING
BETA
2
Twitter Mentions