Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial.

@article{Rutgeerts2005OrnidazoleFP,
  title={Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial.},
  author={Paul J. Rutgeerts and Gert Van Assche and S{\'e}verine Vermeire and G D'Haens and Filip Baert and M. Nasimul Noman and Isolde Aerden and Gert de Hertogh and Karel Geboes and Martin I. Hiele and Andr{\'e} D'Hoore and Freddy M. Penninckx},
  journal={Gastroenterology},
  year={2005},
  volume={128 4},
  pages={856-61}
}
BACKGROUND & AIMS Crohn's disease almost inevitably recurs after ileocolonic resection, and effective prophylactic therapy has not been identified. We investigated the efficacy and safety of ornidazole, a nitroimidazole antibiotic, for the prevention of clinical recurrence of Crohn's disease after curative ileocolonic resection in a placebo-controlled double-blind clinical trial. METHODS Eighty patients were randomized to ornidazole 1 g/day or placebo started within 1 week of resection and… CONTINUE READING

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