Origins of the uricosuric response.

@article{Steele1973OriginsOT,
  title={Origins of the uricosuric response.},
  author={T. H. Steele and Geoffrey Boner},
  journal={The Journal of clinical investigation},
  year={1973},
  volume={52 6},
  pages={1368-75}
}
The acute effects of intravenous (i.v.) probenecid and chlorothiazide on renal urate handling were investigated in paired studies in normal men. Uricosuric responses to these agents were compared in the same subjects, both without and with pyrazinamide (PZA) pretreatment. Assuming that PZA selectively inhibits the tubular secretion of urate and that uricosuric agents act by increasing the excretion of filtered urate, then the uricosuric responses (the increment in urate excretion or clearance… CONTINUE READING
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