Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain.

@article{Dutt2002OriginsOT,
  title={Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain.},
  author={Previn Dutt and Cherie N Spriggs and Peter L Davies and Zongchao Jia and John S. Elce},
  journal={The Biochemical journal},
  year={2002},
  volume={367 Pt 1},
  pages={263-9}
}
The mu- and m-calpains are closely related Ca(2+)-dependent cysteine proteases having different in vitro Ca(2+) requirements ( K (d)), of approx. 25 and 325 microM respectively. The two isoforms are heterodimers of slightly different large (80 kDa) subunits and an identical small (28 kDa) subunit, so that the difference in K (d) values must reside in the large subunits. As assayed here, these K (d) values relate to the Ca(2+) required for the first phase of calpain activation and do not reflect… CONTINUE READING

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