Origins of the concept oxidative phosphorylation

  title={Origins of the concept oxidative phosphorylation},
  author={H. Kalckar},
  journal={Molecular and Cellular Biochemistry},
  • H. Kalckar
  • Published 2005
  • Chemistry, Medicine
  • Molecular and Cellular Biochemistry
In this Symposium, I would perhaps have preferred to confine myself to the description of great ideas in the field of oxidative phosphorylation and a recollection of how these ideas developed and what it led to. The more I worked on it, however, the more I decided to give first priority to hard facts and data recorded and only mobilize recollections here and there. This means, of course, that it will be difficult to avoid mentioning at least a few technical details although they may seem… Expand
Milestones in the history of research on cardiac energy metabolism.
The present study summarizes the history of research on cardiac metabolism from antiquity till the 21st century. It describes important landmarks regarding the discovery of oxygen and of the 3 stepsExpand
In Search of Mitochondrial Mechanisms: Interfield Excursions between Cell Biology and Biochemistry
This paper examines how numerous excursions between biochemistry and cell biology contributed a new understanding of the mechanism of cellular respiration. Expand
Did We Get Pasteur, Warburg, and Crabtree on a Right Note?
Louis Pasteur made the first scientific observation that proliferating cells need oxygen to divide and several authors in the middle of twentieth century reported that glucose is a negative regulator of respiration. Expand
Introduction to the Special Issue on Biology and Agriculture
The historical relations between biology and agriculture have received remarkably little attention. Perhaps this should not be surprising, given that agriculture has not ranked high among theExpand
Energy coupling in Saccharomyces cerevisiae: selected opportunities for metabolic engineering.
This mini-review discusses the importance of the ATP yield for product formation and presents several opportunities for engineering free-energy (ATP) conservation, with a focus on sugar-based product formation by Saccharomyces cerevisiae. Expand
Thiol signalling in skeletal muscle ageing
An age-related loss of muscle mass is associated with increased frailty in the elderly. The effect is felt at both a national scale, with an increased budgetary demand for health services directedExpand
Mitochondrial dysfunction in rabies virus infection of neurons
It is concluded that CVS infection induces mitochondrial dysfunction leading to ROS overgeneration and oxidative stress. Expand
Advances in Bioremediation of Toxic Heavy Metals and Radionuclides in Contaminated Soil and Aquatic Systems
Metals are used in several products essential to humans. However, processes for extraction of the metals generate effluents containing chemical by-products many of which are toxic to living organismsExpand
Development of biological treatment processes for the separation and recovery of radioactive wastes
Abstract: Due to the impact of the rapidly growing demand for energy worldwide, as well as concerns over global warming, there has been a resurgence of interest in nuclear energy in the developedExpand
Cr(VI) mediated hydrolysis of algae cell walls to release TOC for enhanced biotransformation of Cr(VI) by a culture of Cr(VI) reducing bacteria
Hexavalent chromium [Cr(VI)], the most toxic form of chromium, is frequently released into the environment from anthropogenic sources. Cr(VI) mainly occurs in the oxyanionic forms, CrO42− andExpand


In the experiments reported in the present paper an attempt was made to find the components of the phosphorylating system in kidney by reactivating extracts which had lost activity either by aging or by dialysis, it was found that at least two coenzymes, adenylic acid and cozymase, one specific ion, Mg++, and an oxidizable substrate (a dicarboxylic acid) are essential component of the system. Expand
The effect of fumarate on the respiration of liver and kidney tissue.
  • F. Stare
  • Chemistry, Medicine
  • The Biochemical journal
  • 1936
Manometric and chemical experiments are reported on which show the applicability of the fumarateoxaloacetate catalytic theory to the respiration of the liver and kidney tissue of the rabbit. Expand
‘Coupling’ of Phosphorylation with Oxidation of Pyruvic Acid in Brain Tissue
Observations suggested that a cycle of phosphorylation is involved in the enzymatic oxidation of pyruvate. Expand
Energization of active transport by Escherichia coli.
These results show that intact cells can use energy either from oxidations or from phosphorylations to drive active proline transport, and suggest that a similar or identical energy-conserving membrane state is formed from either energy source. Expand
Metabolism of amino-acids: The synthesis of glutamine from glutamic acid and ammonia, and the enzymic hydrolysis of glutamine in animal tissues.
  • H. Krebs
  • Biology, Medicine
  • The Biochemical journal
  • 1935
This investigation found that glutamic acid behaves differently from all the other ax-amino-acids in guinea-pig and rabbit kidneys, in that, although it increases the oxygen uptake even more than any other amino-acid of the i-series, in most cases it actually diminishes ammonia formation. Expand
Molecular Fields of Force
MY article on “Molecular Fields of Force”1 contains a misrepresentation of Prof. J. E. Lennard-Jones's work on this subject, which I much regret and wish to correct. In referring to the degree ofExpand
-Galactoside accumulation in a Mg 2+ -,Ca 2+ -activated ATPase deficient mutant of E.coli.
It is concluded that the ATPase is necessary for the coupling of ATP-hydrolysis to the accumulation of TMG and that the mutant strain TMG-accumulation is abolished. Expand
Über die Atmung der Froschmuskulatur
  • O. Meyerhof
  • Chemistry
  • Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere
  • 2005
Die absolute AtmungsgrSsse der Muskeln . . . . . . . . . 21 Die AtmungsgrSsse der zerschnittenen Muskulatur . . . . 24 Vergleichende Versuehe mit intakten und zerstSrten Leberzellen . . . . . . . . .Expand
Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism
Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism