Origins of immunity: transcription factors and homologues of effector genes of the vertebrate immune system expressed in sea urchin coelomocytes

@article{Pancer1999OriginsOI,
  title={Origins of immunity: transcription factors and homologues of effector genes of the vertebrate immune system expressed in sea urchin coelomocytes},
  author={Zeev Pancer and Jonathan P. Rast and Eric H. Davidson},
  journal={Immunogenetics},
  year={1999},
  volume={49},
  pages={773-786}
}
 Echinoderms share common ancestry with the chordates within the deuterostome clade. Molecular features that are shared between their immune systems and that of mammals thus illuminate the basal genetic framework on which these immune systems have been constructed during evolution. The immune effector cells of sea urchins are the coelomocytes, whose primary function is protection against invasive marine pathogens; here we identify six genes expressed in coelomocytes, homologues of which are… CONTINUE READING
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