Origins of breast cancer subtypes and therapeutic implications

@article{Sims2007OriginsOB,
  title={Origins of breast cancer subtypes and therapeutic implications},
  author={Andrew H Sims and Anthony Howell and Sacha J Howell and Robert B. Clarke},
  journal={Nature Clinical Practice Oncology},
  year={2007},
  volume={4},
  pages={516-525}
}
This Review summarizes and evaluates the current evidence for the cellular origins of breast cancer subtypes identified by different approaches such as histology, molecular pathology, genetic and gene-expression analysis. Emerging knowledge of the normal breast cell types has led to the hypothesis that the subtypes of breast cancer might arise from mutations or genetic rearrangements occurring in different populations of stem cells and progenitor cells. We describe the common distinguishing… CONTINUE READING

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