Origins of biomolecular handedness

  title={Origins of biomolecular handedness},
  author={Stephen Finney Mason},
  • S. Mason
  • Published 1 September 1984
  • Biology
  • Nature
Classical mechanisms proposed for the transition from racemic geochemistry to homochiral biochemistry in terrestrial evolution generally ascribe to chance the particular handed choice of the L-amino acids and the D-sugars by self-replicating systems. The parity-violating weak neutral current interaction gives rise to an energy difference between a chiral molecule and its mirror-image isomer, resulting in a small stabilization of the L-amino acids and the L-peptides in the α-helix and the… 

Chirality and the Origins of Life

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  • Biology
    Origins of Life and Evolution of Biospheres
  • 2015
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  • Shubin Liu
  • Chemistry
    The journal of physical chemistry letters
  • 2020
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There is an alternative “cybernetic” mechanism, a spontaneous generation and self-propagation of asymmetry as a consequence of kinetic bistability in the course of the evolution of open systems.

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Sensitivity of a nonequilibrium chemical system to small symmetry-breaking influences is analyzed in the context of chiral-symmetry breaking. For a hypothetical model system, with realistic kinetic

Energy inequivalence of peptide enantiomers from parity non-conservation

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