Origins of aberrant DNA methylation in acute myeloid leukemia

  title={Origins of aberrant DNA methylation in acute myeloid leukemia},
  author={Till Schoofs and Wolfgang E. Berdel and Carsten M{\"u}ller-Tidow},
Aberrant DNA methylation patterns are a characteristic feature of cancer including myeloid malignancies such as acute myeloid leukemia (AML). The mechanisms behind aberrant DNA methylation have long remained obscure. New genome-wide studies have elucidated the genome and epigenome of solid tumors and AML. Molecular subtypes of AML were found to exhibit highly distinct DNA methylation profiles. Clonal evolution patterns of AML were recently dissected and might shape epigenetic dysregulation… CONTINUE READING

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