Origins of HIV

@article{Hillis2000OriginsOH,
  title={Origins of HIV},
  author={David M. Hillis},
  journal={Science},
  year={2000},
  volume={288},
  pages={1757 - 1759}
}
Establishing the date when immunodeficiency viruses were transmitted from nonhuman primates to humans should provide a clue to the origin of the AIDS pandemic. In his Perspective, Hillis discusses an important analysis of the molecular divergence of SIV and HIV genes (Korber et al.). This analysis establishes 1931 as the date of origin of the HIV-1 M-group viruses (the principal cause of the AIDS pandemic). Hillis discusses three possible hypotheses of immunodeficiency virus transmission that… Expand
Travel and the spread of HIV-1 genetic variants.
TLDR
Most subtypes and CRFs are represented in Africa, whereas predominance of one or a few subtypes was reported initially elsewhere, which reflects the African origin of the epidemic. Expand
Using human immunodeficiency virus type 1 sequences to infer historical features of the acquired immune deficiency syndrome epidemic and human immunodeficiency virus evolution.
  • K. Yusim, M. Peeters, +6 authors B. Korber
  • Biology, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2001
TLDR
New phylogenetic analysis of an extremely diverse set of human immunodeficiency virus envelope sequences from the Democratic Republic of the Congo suggests an increase in the exponential growth rate of the infected population through time. Expand
Experimental oral polio vaccines and acquired immune deficiency syndrome.
  • E. Hooper
  • Biology, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2001
TLDR
There is a startling coincidence between places in Africa where Dr Hilary Koprowski's CHAT vaccine was fed, and the first appearances in the world of HIV-1 group M and group-M-related AIDS. Expand
An Exploration on HIV/AIDS Funding in South Africa
TLDR
The goal is to identify the origin of these funds that are estimated between US$7 and US$8 billion annually, and determine if the allocation of monies is reaching its potential recipients, and recommendations will be provided for any potential breaks in the logistical chain to ensure those in need are receiving these funds. Expand
Use of phylogenetics in the molecular epidemiology and evolutionary studies of viral infections
TLDR
This review aims to provide, with minimal mathematics and statistics, a practical overview of how phylogenetic methods can be incorporated into virological studies by clinical and laboratory specialists. Expand
STUDY OF HIV-1 TRANSMISSION ACROSS HUMAN CERVICAL TISSUE TO THE LYMPHOID TISSUE USING AN ORGAN CULTURE MODEL
TLDR
The combined cervix and tonsil tissue/cell model may be used to determine the mechanism of sexual transmission of HIV-1 in women at the cellular and molecular level and to evaluate anti-HIV microbicides. Expand
Human Immunodeficiency Virus Immune Cell Receptors, Coreceptors, and Cofactors: Implications for Prevention and Treatment
TLDR
Interestingly, the expression of distinct cellular cofactors partially regulates the rate in which HIV infects each distinct cell type. Expand
Natural infection of wild-born mandrills (Mandrillus sphinx) with two different types of simian immunodeficiency virus.
TLDR
The results indicate that the Sivmnds isolated in Cameroon are a novel type of SIVmnd and have infected Cameroonian mandrills for a long time. Expand
The Global Spread of AIDS and HIV
Acquired Immunodeficiency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) emerged on the global scene in the early 1980s, and since then has become one of the critical factors affecting humanExpand
The Politics of a Scientific Meeting: The Origin-of-AIDS Debate at the Royal Society
  • B. Martin
  • Medicine, Sociology
  • Politics and the Life Sciences
  • 2001
TLDR
Several dimensions of the politics of science are revealed by analysis of this issue, including the power of scientific editors, the use of the mass media, decisions regarding selection of speakers and organization of the meeting, and epistemological assumptions made by participants. Expand
...
1
2
3
4
...

References

SHOWING 1-4 OF 4 REFERENCES
Timing the ancestor of the HIV-1 pandemic strains.
TLDR
Using a comprehensive full-length envelope sequence alignment, the date of the last common ancestor of the main group of HIV-1 is estimated to be 1931 (1915-41). Expand
Origin of HIV type 1 in colonial French Equatorial Africa?
Sociocultural factors during the postcolonial period have been implicated as paramount in generating conditions that promoted both the origin and subsequent epidemic spread of HIV-1 in Africa. WeExpand
Estimating the rate of evolution of the rate of molecular evolution.
A simple model for the evolution of the rate of molecular evolution is presented. With a Bayesian approach, this model can serve as the basis for estimating dates of important evolutionary eventsExpand
A compound poisson process for relaxing the molecular clock.
TLDR
This work introduces a parametric model that relaxes the molecular clock by allowing rates to vary across lineages according to a compound Poisson process and uses Markov chain Monte Carlo integration to evaluate the posterior probability distribution. Expand