Origins and specificity of auto-antibodies in Sm+ SLE patients.

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease accompanied by production of autoantibodies directed to a variety of self-proteins and nucleic acids. The genetic basis of SLE is also complex with at least 40 susceptibility loci identified. This complexity suggests that there are a variety of SLE manifestations; nevertheless, SLE is… (More)
DOI: 10.1016/j.jaut.2018.02.008

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