Origins and impact of the term ‘NSAID’

@article{Buer2014OriginsAI,
  title={Origins and impact of the term ‘NSAID’},
  author={Jonas Kure Buer},
  journal={Inflammopharmacology},
  year={2014},
  volume={22},
  pages={263-267}
}
This article is an historical investigation of the term non-steroidal anti-inflammatory drugs and its acronym NSAIDs. Drug names and categories tend to be taken at face value in everyday practice, as natural categories existing in their own right. The main argument of this article is that the term NSAID is a reminder that drug names and categories are complex cultural and social products that have been created by specific people, for specific purposes, through specific historical processes, and… 

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A JOURNEY OF CELECOXIB FROM PAIN TO CANCER.

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In this review, the most recently developed anti-RA chemical drugs are summarized and the synthesis and biological activities of these various new compounds are discussed.

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Interaction of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) with Reactive Oxygen Species (ROS): Possible Biomedical Implications

Results could be prudently extrapolated to a possible action of NSAIDs in the retardation or inhibition of neuroinflammatory disorders, in which oxidative agents such as ROS were found to be upregulated.

NSAIDS ( Cox-2 inhibitors ) : A safer approach *

The connection between COX-2 inhibitors and CV occasions should be tended to further, albeit moral and safe clinical trials are hard to execute practically speaking, a stepwise approach with proper measures is required for its more secure utilize.

Attenuation of Female Reproductive Hormones in Piroxicam Administered Wistar Rats

Antioxidant Vitamin E helped in antagonizing the effects of Piroxicam, showing less decrease in hormone levels, by decreasing oestrogen, progesterone and gonadotropins levels, NSAIDs can therefore be said to pose negative effects on female fertility.

References

SHOWING 1-10 OF 22 REFERENCES

Old and new drugs used in rheumatoid arthritis: a historical perspective. Part 1: the older drugs.

  • J. Case
  • Medicine
    American journal of therapeutics
  • 2001
The practical use of these drugs is determined by efficacy-toxicity considerations, which have also driven the recent development of the cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs.

A Biochemical Distinction Between Non‐Steroid Anti‐inflammatory and Analgesic Drugs

  • M. Whitehouse
  • Biology, Medicine
    The Journal of pharmacy and pharmacology
  • 1963
. . . . . . . . Phenylbutazone Oxyphenbutazone AmidODnine . . . . . . . . . . . . . . A Biochemical Distinction Between Non-Steroid Anti-inflammatory and Analgesic Drugs Sm,-As alternatives to

Nonsteroid anti-inflammatory agents.

The only way to discover an efficient antiinflammatory agent is to obviate the need for it by discovering the actual mechanism of inflammation, for when specific anti-etiologic therapy is developed, theneed for treatment with NSAIDs is irrelevant.

Anti-inflammatory glucocorticoid drugs: reflections after 60 years

The rather gloomy conclusion is that devising new drugs to reproduce the effect of multi-potent hormones may be a recipe for disaster, in contexts other than simply remedying an endocrine deficiency.

Pharmacological Classification of Steroid Hormones

It is felt that the best solution of the problem is to classify the steroid hormone actions according to the degree to which they are able to imitate or substitute for the function of a certain endocrine gland.

Possible causes of treatment failure with the NSAID.

The clinical efficacy of non-steroidal anti-inflammatory drugs (NSAID) is often disappointing, and the need to perform clinical trials in an appropriate setting in which such determinations can be conveniently carried out points to the necessity of concomitant determination of the plasma levels of all NSAID tested.

BASIC MECHANISMS OF DRUG ACTION.

  • D. Gourley
  • Biology, Medicine
    Fortschritte der Arzneimittelforschung. Progress in drug research. Progres des recherches pharmaceutiques
  • 1964
It is the aim of this review to discuss some of the recent attempts to reveal the basic mechanisms of drug action.

The Rise and Fall of Modern Medicine

The thesis is that despite the significant advances in combatting disease which reached their peak in the post-war years, the promise of modern medicine as the authors are at the end of the century has failed to materialise.

Rise and fall of modern medicine

Relation between ulcerogenic activity of various NSAID and their potency as inhibitors of prostaglandin synthesis in vivo.

A correlation between the activity in the three tests has been found for most NSAID studied, and the results point to inhibition of cyclooxygenase as a common mechanism of action.