Origins and evolutionary diversification of the nuclear receptor superfamily

  title={Origins and evolutionary diversification of the nuclear receptor superfamily},
  author={Gareth I. Owen and Arthur Zelent},
  journal={Cellular and Molecular Life Sciences CMLS},
Nuclear receptors (NRs), which include those for steroid and thyroid hormones as well as retinoids, are encoded by a large gene superfamily that has evolved to regulate nearly every facet of metazoan life, from development to basic metabolism. This article reviews the conservation in structure and function of distinct receptors across different species and attempts to draw conclusions as to the evolution of this gene superfamily. Although sequences related to NRs can be found in plants and… CONTINUE READING
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