Origins and evolution of the mechanisms regulating translation initiation in eukaryotes.

@article{Hernndez2010OriginsAE,
  title={Origins and evolution of the mechanisms regulating translation initiation in eukaryotes.},
  author={Georgina Hern{\'a}ndez and Michael Wrentschur Peter Altmann and Paul Lasko},
  journal={Trends in biochemical sciences},
  year={2010},
  volume={35 2},
  pages={
          63-73
        }
}
Translation in eukaryotes is a complex process that is closely regulated, mainly at the initiation step. Both universal and lineage-specific mechanisms regulate translation initiation. Considerable progress in our understanding of the regulation of translation has been achieved, but how these regulatory mechanisms evolved remains poorly understood. New discoveries in different fields suggest that the mechanisms that regulate translation emerged at different times during the evolution of… CONTINUE READING
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