Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease.

@article{Lee2008OriginsAE,
  title={Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease.},
  author={Seung-Jae Lee},
  journal={Journal of molecular neuroscience : MN},
  year={2008},
  volume={34 1},
  pages={17-22}
}
  • Seung-Jae Lee
  • Published 2008 in Journal of molecular neuroscience : MN
Misfolding and abnormal aggregation of the neuronal protein alpha-synuclein has been implicated in the pathogenesis of Parkinson's disease and related neurological disorders, such as dementia with Lewy bodies. alpha-synuclein is a conventional cytosolic protein and is thought to exert its pathogenic function exclusively in the neuronal cytoplasm in a cell-autonomous manner. However, the current model is being challenged by a series of new observations that demonstrate the presence of alpha… CONTINUE READING
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