Origins and challenges of viral dark matter.

@article{Krishnamurthy2017OriginsAC,
  title={Origins and challenges of viral dark matter.},
  author={Siddharth Ravindran Krishnamurthy and David Wang},
  journal={Virus research},
  year={2017},
  volume={239},
  pages={
          136-142
        }
}
The accurate classification of viral dark matter - metagenomic sequences that originate from viruses but do not align to any reference virus sequences - is one of the major obstacles in comprehensively defining the virome. Depending on the sample, viral dark matter can make up from anywhere between 40 and 90% of sequences. This review focuses on the specific nature of dark matter as it relates to viral sequences. We identify three factors that contribute to the existence of viral dark matter… CONTINUE READING

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