Origins and Immunity Networking Functions of EDS1 Family Proteins.

@article{Lapin2020OriginsAI,
  title={Origins and Immunity Networking Functions of EDS1 Family Proteins.},
  author={Dmitry Lapin and Deepak D. Bhandari and Jane E. Parker},
  journal={Annual review of phytopathology},
  year={2020}
}
The EDS1 family of structurally unique lipase-like proteins EDS1, SAG101, and PAD4 evolved in seed plants, on top of existing phytohormone and nucleotide-binding-leucine-rich-repeat (NLR) networks, to regulate immunity pathways against host-adapted biotrophic pathogens. Exclusive heterodimers between EDS1 and SAG101 or PAD4 create essential surfaces for resistance signaling. Phylogenomic information, together with functional studies in Arabidopsis and tobacco, identify a coevolved module… 
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51 Citations
Highly Influential Citations
6
Background Citations
22
Methods Citations
1
Results Citations
1

51 Citations

Arabidopsis cell surface LRR immune receptor signaling through the EDS1-PAD4-ADR1 node
TLDR
It is proposed that the EDS1-PAD4-ADR1 node is an essential component and convergence point for immune signaling cascades activated by both surface-resident LRR-RP receptors and intracellular NLR receptors.
The EDS1-PAD4-ADR1 node mediates Arabidopsis pattern-triggered immunity.
TLDR
It is proposed that the EDS1-PAD4-ADR1 node is a convergence point for defence signalling cascades, activated by both surface-resident and intracellular LRR receptors, in conferring pathogen immunity.
Differential requirement for the EDS1 catalytic triad in A. thaliana and N. benthamiana
TLDR
Intriguingly, mutations within the catalytic triad of Solanaceae EDS1 can abolish or enhance TNL immunity in N. benthamiana and Reinforcing PRR signaling in Arabidopsis might be a derived function of the TNL/EDS1 immune sector.
EDS1 signalling: At the nexus of intracellular and surface receptor immunity.
Two interacting transcriptional coactivators cooperatively control plant immune responses
TLDR
It is shown that NPR1 and EDS1 synergistically activate Pathogenesis-Related genes and plant defenses by forming a protein complex and co-opting with Mediator and an elegant interplay of key coactivators with Mediation is revealed.
Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity
TLDR
Genetic and molecular evidence is provided for exclusive EDS1/SAG101/NRG1 and E DS1/PAD4/ADR1 co-functions in TNL immunity and shows effector recognition-dependent association of NRG1 with EDS 1 and SAG101, but not PAD4.
A novel allele in the Arabidopsis thaliana MACPF protein CAD1 results in deregulated immune signaling.
TLDR
It is shown that cad1-5 mutants display deregulated immune signaling and symptoms of autoimmunity dependent on the lipase-like protein ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1), suggesting that CAD1 integrity is monitored by the plant immune system.
A novel allele in the Arabidopsis thaliana MACPF protein CAD1 results in deregulated immune signaling
TLDR
It is shown that cad1-5 mutants display deregulated immune signaling and symptoms of autoimmunity dependent on the lipase-like protein ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1), suggesting that CAD1 integrity is monitored by the plant immune system.
Differential EDS1 requirement for cell death activities of plant TIR-domain proteins
TLDR
A large-scale phylogenetic analysis of TIR domains from 39 algae and land plant species is used to provide a new phylogeny-based plant TIR classification and identify TIR groups that appear to have evolved with and are dependent on E DS1, while others have EDS1-independent activity.
NOD-like receptor-mediated plant immunity: from structure to cell death.
TLDR
Structural and biochemical analyses point to host cell membranes as a convergence point for activated plant NLRs and the disruption of cellular ion homeostasis as a possible major factor in NLR-triggered cell death signalling.
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