Origins and Immunity Networking Functions of EDS1 Family Proteins.
@article{Lapin2020OriginsAI, title={Origins and Immunity Networking Functions of EDS1 Family Proteins.}, author={Dmitry Lapin and Deepak D. Bhandari and Jane E. Parker}, journal={Annual review of phytopathology}, year={2020} }
The EDS1 family of structurally unique lipase-like proteins EDS1, SAG101, and PAD4 evolved in seed plants, on top of existing phytohormone and nucleotide-binding-leucine-rich-repeat (NLR) networks, to regulate immunity pathways against host-adapted biotrophic pathogens. Exclusive heterodimers between EDS1 and SAG101 or PAD4 create essential surfaces for resistance signaling. Phylogenomic information, together with functional studies in Arabidopsis and tobacco, identify a coevolved module…
45 Citations
Arabidopsis cell surface LRR immune receptor signaling through the EDS1-PAD4-ADR1 node
- BiologybioRxiv
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It is proposed that the EDS1-PAD4-ADR1 node is an essential component and convergence point for immune signaling cascades activated by both surface-resident LRR-RP receptors and intracellular NLR receptors.
The EDS1-PAD4-ADR1 node mediates Arabidopsis pattern-triggered immunity.
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It is proposed that the EDS1-PAD4-ADR1 node is a convergence point for defence signalling cascades, activated by both surface-resident and intracellular LRR receptors, in conferring pathogen immunity.
Differential requirement for the EDS1 catalytic triad in A. thaliana and N. benthamiana
- BiologybioRxiv
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Intriguingly, mutations within the catalytic triad of Solanaceae EDS1 can abolish or enhance TNL immunity in N. benthamiana and Reinforcing PRR signaling in Arabidopsis might be a derived function of the TNL/EDS1 immune sector.
EDS1 signalling: At the nexus of intracellular and surface receptor immunity.
- BiologyCurrent opinion in plant biology
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Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity
- BiologyNature communications
- 2021
Genetic and molecular evidence is presented for exclusive EDS1/SAG101/NRG1 and E DS1/PAD4/ADR1 co-functions in TNL immunity and effector recognition-dependent interaction of NRG1 with EDS 1 and SAG101, but not PAD4.
Two interacting transcriptional coactivators cooperatively control plant immune responses
- BiologybioRxiv
- 2021
It is shown that NPR1 and EDS1 synergistically activate Pathogenesis-Related genes and plant defenses by forming a protein complex and co-opting with Mediator and an elegant interplay of key coactivators with Mediation is revealed.
Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity
- BiologybioRxiv
- 2020
Genetic and molecular evidence is provided for exclusive EDS1/SAG101/NRG1 and E DS1/PAD4/ADR1 co-functions in TNL immunity and shows effector recognition-dependent association of NRG1 with EDS 1 and SAG101, but not PAD4.
A novel allele in the Arabidopsis thaliana MACPF protein CAD1 results in deregulated immune signaling.
- BiologyGenetics
- 2021
It is shown that cad1-5 mutants display deregulated immune signaling and symptoms of autoimmunity dependent on the lipase-like protein ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1), suggesting that CAD1 integrity is monitored by the plant immune system.
A novel allele in the Arabidopsis thaliana MACPF protein CAD1 results in deregulated immune signaling
- BiologybioRxiv
- 2021
It is shown that cad1-5 mutants display deregulated immune signaling and symptoms of autoimmunity dependent on the lipase-like protein ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1), suggesting that CAD1 integrity is monitored by the plant immune system.
Differential EDS1 requirement for cell death activities of plant TIR-domain proteins
- Environmental SciencebioRxiv
- 2021
A large-scale phylogenetic analysis of TIR domains from 39 algae and land plant species is used to provide a new phylogeny-based plant TIR classification and identify TIR groups that appear to have evolved with and are dependent on E DS1, while others have EDS1-independent activity.