Origins and Immunity Networking Functions of EDS1 Family Proteins.

@article{Lapin2020OriginsAI,
  title={Origins and Immunity Networking Functions of EDS1 Family Proteins.},
  author={Dmitry Lapin and Deepak D. Bhandari and Jane E. Parker},
  journal={Annual review of phytopathology},
  year={2020}
}
The EDS1 family of structurally unique lipase-like proteins EDS1, SAG101, and PAD4 evolved in seed plants, on top of existing phytohormone and nucleotide-binding-leucine-rich-repeat (NLR) networks, to regulate immunity pathways against host-adapted biotrophic pathogens. Exclusive heterodimers between EDS1 and SAG101 or PAD4 create essential surfaces for resistance signaling. Phylogenomic information, together with functional studies in Arabidopsis and tobacco, identify a coevolved module… 
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