Original nootropic drug Noopept prevents memory deficit in rats with muscarinic and nicotinic receptor blockade

@article{Radionova2008OriginalND,
  title={Original nootropic drug Noopept prevents memory deficit in rats with muscarinic and nicotinic receptor blockade},
  author={K. S. Radionova and A. P. Belnik and R. Ostrovskaya},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2008},
  volume={146},
  pages={59-62}
}
  • K. S. Radionova, A. P. Belnik, R. Ostrovskaya
  • Published 2008
  • Chemistry, Medicine
  • Bulletin of Experimental Biology and Medicine
    • Antiamnesic activity of Noopept was studied on the original three-way model of conditioned passive avoidance response, which allows studying spatial component of memory. Cholinoceptor antagonists of both types (scopolamine and mecamylamine) decreased entry latency and reduced the probability for selection of the safe compartment. Noopept abolished the antiamnesic effect of cholinoceptor antagonists and improved spatial preference. 
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    References

    SHOWING 1-10 OF 10 REFERENCES
    Dipeptide preparation Noopept prevents scopolamine-induced deficit of spatial memory in BALB/c mice
    • 6
    • PDF
    Differential roles for nicotinic and muscarinic cholinergic receptors in sustained visuo-spatial attention? A study using a 5-arm maze protocol in mice
    • 23
    The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model
    • 39
    Inhibition of hippocampal function in mild cognitive impairment: targeting the cholinergic hypothesis
    • 98
    The Cognitive Psychopharmacology of Alzheimer's Disease: Focus on Cholinergic Systems
    • 81
    Synthesis and antiamnesic activity of a series of N-acylprolyl-containing dipeptides
    • 49
    Psychiatric Drug Discovery and Development
    • K. Maubach
    • Medicine
    • Expert opinion on investigational drugs
    • 2003
    • 7
    Current Concepts in Intestinal Peptide Absorption
    • G. Fricker, J. Drewe
    • Chemistry, Medicine
    • Journal of peptide science : an official publication of the European Peptide Society
    • 1996
    • 40
    Biological Basis of Individual Sensitivity to Psychotropic Drugs
    • 1994
    Preclinical and clinical behavioral paradigms for testing drugs that affect learning and memory processes.
    • D. Reddy
    • Psychology, Medicine
    • Methods and findings in experimental and clinical pharmacology
    • 1998
    • 5