Original insights on thrombospondin-1-related antireceptor strategies in cancer

  title={Original insights on thrombospondin-1-related antireceptor strategies in cancer},
  author={Albin Jeanne and Christophe Schneider and Laurent Martiny and St{\'e}phane Dedieu},
  booktitle={Front. Pharmacol.},
Thrombospondin-1 (TSP-1) is a large matricellular glycoprotein known to be overexpressed within tumor stroma in several cancer types. While mainly considered as an endogenous angiogenesis inhibitor, TSP-1 exhibits multifaceted functionalities in a tumor context depending both on TSP-1 concentration as well as differential receptor expression by cancer cells and on tumor-associated stromal cells. Besides, the complex modular structure of TSP-1 along with the wide variety of its soluble ligands… CONTINUE READING
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