Original article: Myrmecia pilosula (Jack Jumper) ant venom: identification of allergens and revised nomenclature

  title={Original article: Myrmecia pilosula (Jack Jumper) ant venom: identification of allergens and revised nomenclature},
  author={Michael D. Wiese and S. G. A. Brown and Tim Chataway and Noel W Davies and Robert W. Milne and Susan Aulfrey and Robert J. Heddle},
Background:  The ‘Jack Jumper Ant’ (JJA; Myrmecia pilosula species complex) is the major cause of ant sting anaphylaxis in Australia. Our aims were to determine the allergenicity of previously described venom peptides in their native forms, identify additional allergens and if necessary, update nomenclature used to describe the allergens according to International Union of Immunological Societies criteria. 

Factors influencing the quality of Myrmecia pilosula (Jack Jumper) ant venom for use in in vitro and in vivo diagnoses of allergen sensitization and in allergen immunotherapy

  • T. WanandyH. Dwyer M. Wiese
  • Medicine, Biology
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2017
Allergen immunotherapy uses pharmaceutical preparations derived from naturally occurring source materials, which contain water‐soluble allergenic components responsible for allergic reactions. The

Stability of Myrmecia pilosula (Jack Jumper) Ant venom for use in immunotherapy.

Causes of ant sting anaphylaxis in Australia: the Australian Ant Venom Allergy Study

Objective: To determine the Australian native ant species associated with ant sting anaphylaxis, geographical distribution of allergic reactions, and feasibility of diagnostic venom‐specific IgE

Ant venoms

  • D. Hoffman
  • Chemistry
    Current opinion in allergy and clinical immunology
  • 2010
Ants share some common proteins in venoms, but each group appears to have a number of possibly unique components and further proteomic studies should expand and clarify knowledge of these fascinating animals.

Current Advances in Immunological Studies on the Vespidae Venom Antigen 5: Therapeutic and Prophylaxis to Hypersensitivity Responses

An update on the knowledge regarding the immune response and the therapeutic potential of Antigen 5 derived from Hymenoptera venom is provided and results confirm that the identification and topology of epitopes are crucial to the improvement of hypersensitivity diagnostic methods.

Anaphylaxis due to indian black ant bite [Camponotus compressus] and a short review of literature

Anaphylaxis and death have been reported due to bite by many species of ants such as fire ant, carpenter ant, black ant (samsum), etc, but anaphyliasis due to the bite of the Common Indian Black Ant is unusual, and has rarely been reported.



Separation of jumper ant (Myrmecia pilosula) venom allergens: A novel group of highly basic proteins

The sting of the jumper ant causes severe allergic reactions, including anaphylaxis in sensitized individuals, and two of the major allergens have been cloned, immunocharacterized and nucleotide‐sequenced and they encode 112 and 75 residue polypeptides, respectively.

Expression of jumper ant (Myrmecia pilosula) venom allergens: Post‐translational processing of allergen gene products

N‐terminal analyses of electrophoretically‐separated allergenic polypeptides of the venom of the jumper ant M. pilosula showed that five out of the six allergenic polypeptides identified are

Proteomic analysis of Myrmecia pilosula (jack jumper) ant venom.

Characterisation of major peptides in 'jack jumper' ant venom by mass spectrometry.

Immediate allergic reactions to Myrmecia ant stings: immunochemical analysis of Myrmecia venoms

Sera with IgE reactivity to only a single Myrmecia venom most often recognize M. pilosula venom although all six venoms appear capable of inducing IgE antibodies.

Prevalence, severity, and natural history of jack jumper ant venom allergy in Tasmania.

M pilosula sting exposure in Tasmania is excessive compared with that found in mainland Australia, and there is a high systemic reaction risk in allergic people on re-sting.

Prevalence of severe ant-venom allergy in southeastern Australia.

Fatal anaphylaxis following jack jumper ant sting in southern Tasmania

There is potential to prevent deaths by careful education of people with known allergy, prescribing of adrenaline for auto‐injection and development of an effective hyposensitisation therapy.

Recombinant Hymenoptera venom allergens

There is considerable potential for improvement of both diagnosis and immunotherapy of Hymenoptera venom allergy and recombinant venom allergens are available today and offer several promising approaches to achieve such an improvement.