Original antigenic sin in dengue.

  title={Original antigenic sin in dengue.},
  author={Scott B. Halstead and S Rojanasuphot and N Sangkawibha},
  journal={The American journal of tropical medicine and hygiene},
  volume={32 1},
Sequential blood samples were obtained from eight Thai children before, during and 3-5 months after hospitalization for dengue shock syndrome. All patients experienced a secondary-type antibody response as evidenced by hemagglutination-inhibition antibody responses in acute and convalescent sera. Dengue 2 viruses were recovered from two patients. In their pre-illness blood sample, all children had monotypic neutralizing antibodies; five to dengue 1, two to dengue 3 and one to dengue 4. The… CONTINUE READING


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