Origin-specific unwinding of herpes simplex virus 1 DNA by the viral UL9 and ICP8 proteins: visualization of a specific preunwinding complex.

@article{Makhov2003OriginspecificUO,
  title={Origin-specific unwinding of herpes simplex virus 1 DNA by the viral UL9 and ICP8 proteins: visualization of a specific preunwinding complex.},
  author={Alexander M Makhov and Sam S-K Lee and I Robert Lehman and Jack D. Griffith},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 3},
  pages={898-903}
}
Herpes simplex virus 1 contains three origins of replication; two copies of oriS and one of a similar sequence, oriL. Here, the combined action of multiple factors known or thought to influence the opening of oriS are examined. These include the viral origin-binding protein, UL9, and single-strand binding protein ICP8, host cell topoisomerase I, and superhelicity of the DNA template. By using electron microscopy, it was observed that when ICP8 and UL9 proteins were added together to oriS… CONTINUE READING

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Herpes simplex viruses: mechanisms of DNA replication.

Cold Spring Harbor perspectives in biology • 2012
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