Origin plasticity during budding yeast DNA replication in vitro.

@article{Gros2014OriginPD,
  title={Origin plasticity during budding yeast DNA replication in vitro.},
  author={Julien Gros and Sujan Devbhandari and Dirk Remus},
  journal={The EMBO journal},
  year={2014},
  volume={33 6},
  pages={621-36}
}
The separation of DNA replication origin licensing and activation in the cell cycle is essential for genome stability across generations in eukaryotic cells. Pre-replicative complexes (pre-RCs) license origins by loading Mcm2-7 complexes in inactive form around DNA. During origin firing in S phase, replisomes assemble around the activated Mcm2-7 DNA helicase. Budding yeast pre-RCs have previously been reconstituted in vitro with purified proteins. Here, we show that reconstituted pre-RCs… CONTINUE READING
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