Origin of the sequence-dependent polyproline II structure in unfolded peptides.

@article{Kentsis2005OriginOT,
  title={Origin of the sequence-dependent polyproline II structure in unfolded peptides.},
  author={Alex Kentsis and Mihaly Mezei and R. Ben Osman},
  journal={Proteins},
  year={2005},
  volume={61 4},
  pages={769-76}
}
Recent studies have indicated that the unfolded states of polypeptides contain a substantial amount of polyproline type II (P(II)) structure. This energetically and structurally preorganized state may contribute to the reduction of the folding search, as well as to the recognition of intrinsically unstructured proteins and polyproline ligands. Using Monte Carlo simulations of natively unfolded peptides in the presence of explicit aqueous solvation, we observe that residue-specific P(II… CONTINUE READING