Origin of the inhibitory activity of 4-O-substituted sialic derivatives of human parainfluenza virus

Abstract

Human parainfluenza virus (hPIV) is a serious human pathogen causing upper and lower respiratory tract disease, yet there are no effective vaccines or therapies to control parainfluenza virus infections. Recently, we found that 4-O-substituted sialic derivatives have potent inhibitory activity against hPIV-1, whereas the anti-influenza inhibitor Zanamivir… (More)
DOI: 10.1007/s10719-012-9384-3

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