Origin of the increased activity of beta-glucuronidase in the soluble fraction of rat mammary tumors during ovariectomy-induced regression.

@article{Beem1987OriginOT,
  title={Origin of the increased activity of beta-glucuronidase in the soluble fraction of rat mammary tumors during ovariectomy-induced regression.},
  author={E P Beem and Michel J. X. Hillebrand and C Benckhuijsen and Bernard Overdijk},
  journal={Cancer research},
  year={1987},
  volume={47 15},
  pages={3980-7}
}
The activity of beta-glucuronidase in methyl-N-nitrosourea-induced rat mammary tumors regressing after ovariectomy was studied. beta-Glucuronidase, acid phosphatase, and beta-hexosaminidase were similarly increased in the lysosome-rich fraction of regressing compared to growing tumors, whereas in the soluble fraction, a 5-fold increase in the activity of beta-glucuronidase midway regression was not paralleled by an increase in the specific activity of the other two enzymes. Results of… CONTINUE READING