Origin of the heavy and light protomers of androgen-binding protein from the rat testis.

@article{Larrea1981OriginOT,
  title={Origin of the heavy and light protomers of androgen-binding protein from the rat testis.},
  author={Fernando Larrea and Neal A. Musto and Glen L Gunsalus and Jennie Powell Mather and Caroline Bardin},
  journal={The Journal of biological chemistry},
  year={1981},
  volume={256 23},
  pages={12566-73}
}
Androgen-binding protein (ABP) isolated from rat epididymides by androgen affinity chromatography is a dimer with a native molecular weight of 85,000. When fractionated on sodium dodecyl sulfate gels two components were identified which were present in a 3:1 ratio; these were designated heavy (H) and light (L) (Mr of 45,000 and 41,000), respectively. The fact that H and L both have steroid binding sites and that they can be cross-linked suggests that both are protomers of native ABP. NH2… CONTINUE READING