Origin of the eukaryotic nucleus determined by rate-invariant analysis of rRNA sequences

  title={Origin of the eukaryotic nucleus determined by rate-invariant analysis of rRNA sequences},
  author={James Alan Lake},
  • J. Lake
  • Published 1 January 1988
  • Biology
  • Nature
The origin of the eukaryotic nucleus is difficult to reconstruct. Eukaryotic organelles (chloroplast, mitochondrion) are eii bacterial1,2 endosymbionts3,but the source of nuclear genes has been obscured by multiple nucleotide substitutions. Using evolutionary parsimony4, a newly developed rate-invariant treeing algorithm, the eukaryotic ribosomal rRNA genes are shown to have evolved from the eocytes5, a group of extremely thermophilic, sulphur-metabolizing, anucleate cells. The deepest… 

Origin of eukaryotes from within archaea, archaeal eukaryome and bursts of gene gain: eukaryogenesis just made easier?

  • E. Koonin
  • Biology
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2015
Comparative genomic analysis clearly shows that the last eukaryotic common ancestor (LECA) possessed most of the signature complex features of modern eUKaryotic cells, in particular the mitochondria, the endomembrane system including the nucleus, an advanced cytoskeleton and the ubiquitin network.

Ribosomal RNA Phylogenies

Considering bacterial and chloroplastic c-type cytochomes together with cytochrome c, the first universal phylogenetic tree has been established, but in this tree, the Eukaryote kingdom constituted nothing but a small internal branch of the bacterial tree.

The archaebacterial origin of eukaryotes

The analyses favor a topology that supports the eocyte hypothesis rather than archaebacterial monophyly and the 3-domains tree of life, which is thought to be central to understanding the evolution of the eukaryotic cell.

Origin of eukaryotic cell nuclei by symbiosis of Archaea in Bacteria is revealed by homology-hit analysis

It is indicated that yeast ORFs related to the nucleus may share their origins with archaeal ORFs, whereas ORFs that are related toThe cytoplasm may share the origins with bacterial ORFs.

The Deep Archaeal Roots of Eukaryotes

A comprehensive set of 355 eukaryotic genes of apparent archaeal origin identified through ortholog detection and phylogenetic analysis is described and it is indicated that, for the majority of these genes, the preferred tree topology is one with the eUKaryotic branch placed outside the extant diversity of archaea.

Eukaryotic origins: String analysis of 5S ribosomal RNA sequences from some relevant organisms

The ability of the PHYLOGEN tree-forming programs to tease plausible trees from such small molecules suggests that the mode of analysis rather than the size of the molecule is often a major limitation in the reconstruction of acceptable ancient phylogenies.

Small ribosomal subunit RNA sequences, evolutionary relationships among different life forms, and mitochondrial origins

A tree was constructed from a structurally conserved area in an alignment of 83 small ribosomal subunit sequences of eukaryotic, archaebacterial, eubacterial, plastidial, and mitochondrial origin and found it capable of faith-fully reconstructing a branching topology that involved very unequal evolutionary rates.

A New Aspect to the Origin and Evolution of Eukaryotes

This paper suggests, based on the energetic aspect of genome organization, that the emergence of eukaryotes was promoted by the establishment of an efficient energy-converting organelle, such as the mitochondrion, which was acquired by the endosymbiosis of ancient α-purple photosynthetic Gram-negative eubacteria that reorganized the prokaryotic metabolism of the archaebacterial-like ancestral host cells.



Eocytes: a new ribosome structure indicates a kingdom with a close relationship to eukaryotes.

It is suggested that an appropriate kingdom name for this group of ribosomes from eubacteria, archaebacteria, eukaryotes, and a group of sulfur-dependent bacteria would be the Eocyta.

Pronounced structural similarities between the small subunit ribosomal RNA genes of wheat mitochondria and Escherichia coli.

The data establish that the ancestry of the wheat mitochondrial 18S rRNA gene can be traced directly and specifically to the eubacterial primary kingdom, and the data provide compelling support for a relatively recent xenogenous (endosymbiotic) origin of plant mitochondria from eubacteria-like organisms.

A comparison of the small ribosomal RNA genes from the mitochondrial DNA of the great apes and humans: sequence, structure, evolution, and phylogenetic implications.

Phylogenetic inferences drawn from the sequence comparisons support the notion of an approximately equidistant relationship among chimpanzees, gorilla, and man, and suggest that the gorilla and the chimpanzees may be more closely related to one another than they are to man.

The phylogeny of prokaryotes.

A basic evolutionary dichotomy is suggested by the diversion of the archaebacteria and the eubacteria and possible inter-relationships of the former and eukaryotic organisms are discussed.

The primary structure of 16S rDNA from Zea mays chloroplast is homologous to E. coli 16S rRNA

The nucleotide sequence of ribosomal DNA coding for 16S rRNA from Zea mays chloroplast has been determined. A comparison with the 16S rRNA sequence from Escherichia coli reveals strong homology and

A rate-independent technique for analysis of nucleic acid sequences: evolutionary parsimony.

  • J. Lake
  • Biology
    Molecular biology and evolution
  • 1987
The method of evolutionary parsimony accurately predicts the tree, even when substitution rates differ greatly in neighboring peripheral branches (conditions under which parsimony will consistently fail), as the number of substitutions in peripheral branches becomes fewer, the parsimony and the evolutionary-parsimony solutions converge.

Reduction of molecular sulphur by methanogenic bacteria

It is reported that in the presence of molecular sulphur, methanogenic bacteria form large amounts of H2S by dissimilatory sulphur reduction, in addition to methane, which indicates a closer evolutionary relationship between the two groups than has been previously believed.

The Analysis of Natural Microbial Populations by Ribosomal RNA Sequences

Technical strategies are described which useinant DNA methodology and rapid nucleotide sequence determinations to analyze phylogenetic and quantitative aspects of mixed, naturally occurring microbial populations.