Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States.

@article{Lanciotti1999OriginOT,
  title={Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States.},
  author={Robert S. Lanciotti and John T. Roehrig and Vincent Deubel and J. F. Smith and Michael D. Parker and Keith E Steele and Bruce J. Crise and Kate E. Volpe and Mary B. Crabtree and J. H. Scherret and Roy A. Hall and John S. Mackenzie and C. Bruce Cropp and B. Panigrahy and Eileen Noel Ostlund and Beverly J. Schmitt and Mertyn Malkinson and Caroline Banet and J Weissman and Nicholas Komar and Harry M. Savage and Ward B. Stone and Tracey S McNamara and Duane J. Gubler},
  journal={Science},
  year={1999},
  volume={286 5448},
  pages={
          2333-7
        }
}
In late summer 1999, an outbreak of human encephalitis occurred in the northeastern United States that was concurrent with extensive mortality in crows (Corvus species) as well as the deaths of several exotic birds at a zoological park in the same area. Complete genome sequencing of a flavivirus isolated from the brain of a dead Chilean flamingo (Phoenicopterus chilensis), together with partial sequence analysis of envelope glycoprotein (E-glycoprotein) genes amplified from several other… 

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References

SHOWING 1-10 OF 16 REFERENCES

Extensive nucleotide changes and deletions within the envelope glycoprotein gene of Euro-African West Nile viruses.

TLDR
The distribution of virus subtypes into two lineages did not correlate with host preference or geographical origin, and the isolation of closely related subtypes in distant countries is consistent with WN viruses being disseminated by migrating birds.

Indigenous wild birds of the Nile Delta as potential West Nile virus circulating reservoirs.

TLDR
The hooded crow proved to be the best virus circulator in titer as well as duration and the bird-mosquito-bird cycle of transmission was easily demonstrated, as an example of what may occur under natural conditions in the endemic environment of the Nile Delta of Egypt.

Identification of monoclonal antibodies capable of differentiating antigenic varieties of eastern equine encephalitis viruses.

TLDR
Three monoclonal antibody reagents useful in the serological identification of varieties of eastern equine encephalitis (EEE) viruses were isolated and characterized, specific for the E1 glycoprotein of their homologous viruses.

Antigenic structure of the Murray Valley encephalitis virus E glycoprotein.

TLDR
While the antigenic domains on viruses within the SLE virus serocomplex are quite similar, epitopes involved in virus neutralization or protection from virus challenge may vary and can be topologically distinct.

Antigenic relationships between flaviviruses as determined by cross-neutralization tests with polyclonal antisera.

TLDR
The recently established virus family Flaviviridae contains at least 68 recognized members; sixty-six of these viruses were tested by cross-neutralization in cell cultures and 17 other viruses were not sufficiently related to warrant inclusion in any of these complexes.

Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution.

TLDR
The sequence of the entire RNA genome of the type flavivirus, yellow fever virus, has been obtained and implies that mature viral proteins are produced by posttranslational cleavage of a polyprotein precursor and has implications for flaviv virus RNA replication and for the evolutionary relation of this virus family to other RNA viruses.