Origin of the Genetic Code

@article{Crick1967OriginOT,
  title={Origin of the Genetic Code},
  author={Francis H. C. Crick},
  journal={Nature},
  year={1967},
  volume={213},
  pages={119-119}
}
  • F. Crick
  • Published 14 January 1967
  • Biology
  • Nature

The origin of the genetic code.

  • B. Thomas
  • Biology
    Biochemical and biophysical research communications
  • 1970

The significance of redundancy in the genetic code.

  • M. Dufton
  • Biology
    Journal of theoretical biology
  • 1983

A possible step in the origin of the genetic code.

It is suggested that the earliest coding polynucleotides contained a high proportion of alternating sequences of purines and pyrimidines, and that these sequences coded for polypeptides in which

Evolutionary changes in the genetic code

The genetic code has been influenced by directional mutation pressure affecting the base composition of DNA, sometimes in the direction of increased GC content and at other times, in the direction of

[Origin and evolution of the genetic code].

We propose a quantitative model which suggests that the present genetic code appeared under the influence of mutations, while optimizing its own resistance against their effects. Its evolution was

The puzzling origin of the genetic code.

Is there a higher level genetic code that directs evolution?

  • L. Caporale
  • Biology
    Molecular and Cellular Biochemistry
  • 2004
Flexibility in the genetic code allows information encoding structural, and therefore functional, properties of RNA and DNA to be transmitted simultaneously by a protein-coding sequence of DNA.

The origin of the genetic code

A new approach to the origin of the genetic code is proposed based on some regularities in the nucleotide distribution pattern of the code, which proposes a selective mechanism worked among the protobionts so that less frequent nucleotides became associated with more abundant amino acids in the primordial conditions, thus leading to the present codon catalogue.

The path to the genetic code.

Evolution and multilevel optimization of the genetic code.

The specific 64-to-20 mapping found in the genetic code may have been optimized for permitting protein-coding regions to carry this extra information and it is suggested that this property may have evolved as a side benefit of selection to minimize the negative effects of frameshift errors.
...

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Origin of the Genetic Code

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In certain mutants a single base change alters the meaning of a messenger codon in such a way that, instead of spelling out an amino-acid, it spells out chain termination. Mutants in a quite

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