Origin of spontaneous activity in neonatal and adult rat bladders and its enhancement by stretch and muscarinic agonists.

@article{Kanai2007OriginOS,
  title={Origin of spontaneous activity in neonatal and adult rat bladders and its enhancement by stretch and muscarinic agonists.},
  author={Anthony J Kanai and J. Roppolo and Youko Ikeda and Irina V. Zabbarova and Changfeng Tai and Lori Ann Birder and David Griffiths and William Chet de Groat and Cl{\'e}mentine Fry},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={292 3},
  pages={F1065-72}
}
This study examined the origin of spontaneous activity in neonatal and adult rat bladders and the effect of stretch and muscarinic agonists and antagonists on spontaneous activity. Rats were anesthetized and their bladders were excised, cannulated, and loaded with voltage- and Ca(2+)-sensitive dyes. Intracellular Ca(2+) and membrane potential transients were mapped using photodiode arrays in whole bladders, bladder sheets, or cross-section preparations at 37 degrees C. Intravesical pressure was… CONTINUE READING

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