Origin of scaling behavior of protein packing density: A sequential Monte Carlo study of compact long chain polymers

@article{Zhang2003OriginOS,
  title={Origin of scaling behavior of protein packing density: A sequential Monte Carlo study of compact long chain polymers},
  author={Jinfeng Zhang and Rong Chen and Chao Tang and Jie Liang},
  journal={Journal of Chemical Physics},
  year={2003},
  volume={118},
  pages={6102-6109}
}
Single domain proteins are thought to be tightly packed. The introduction of voids by mutations is often regarded as destabilizing. In this study we show that packing density for single domain proteins decreases with chain length. We find that the radius of gyration provides a poor description of protein packing but the alpha contact number we introduce here characterize proteins well. We further demonstrate that protein-like scaling relationship between packing density and chain length is… Expand

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