Origin of pain in migraine: evidence for peripheral sensitisation

@article{Olesen2009OriginOP,
  title={Origin of pain in migraine: evidence for peripheral sensitisation},
  author={J. Staun Olesen and Rami Burstein and Messoud Ashina and Peer Carsten Tfelt-Hansen},
  journal={The Lancet Neurology},
  year={2009},
  volume={8},
  pages={679-690}
}
  • J. Staun Olesen, Rami Burstein, +1 author Peer Carsten Tfelt-Hansen
  • Published 2009
  • Medicine
  • The Lancet Neurology
  • Migraine is the most common neurological disorder, and much has been learned about its mechanisms in recent years. However, the origin of painful impulses in the trigeminal nerve is still uncertain. Despite the attention paid recently to the role of central sensitisation in migraine pathophysiology, in our view, neuronal hyperexcitability depends on activation of peripheral nociceptors. Although the onset of a migraine attack might take place in deep-brain structures, some evidence indicates… CONTINUE READING

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