Origin of pain in migraine: evidence for peripheral sensitisation

@article{Olesen2009OriginOP,
  title={Origin of pain in migraine: evidence for peripheral sensitisation},
  author={J. Olesen and R. Burstein and M. Ashina and P. Tfelt-Hansen},
  journal={The Lancet Neurology},
  year={2009},
  volume={8},
  pages={679-690}
}
Migraine is the most common neurological disorder, and much has been learned about its mechanisms in recent years. However, the origin of painful impulses in the trigeminal nerve is still uncertain. Despite the attention paid recently to the role of central sensitisation in migraine pathophysiology, in our view, neuronal hyperexcitability depends on activation of peripheral nociceptors. Although the onset of a migraine attack might take place in deep-brain structures, some evidence indicates… Expand
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Paper Mentions

Interventional Clinical Trial
Botox acts on nerve endings, yet there are no nerve endings inside the muscle, where they are typically injected. All nerves terminate on the fascia, where ASIS device can precisely… Expand
ConditionsChronic Migraine More than15 Days Per Month, and Lasting 4 Hours a Day or Longer.
InterventionDrug

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