Origin of myofibroblasts in the fibrotic liver in mice.

  title={Origin of myofibroblasts in the fibrotic liver in mice.},
  author={Keiko Iwaisako and Chunyan Jiang and Mingjun Zhang and Min Cong and Thomas Joseph Moore-Morris and Tae Jun Park and Xiao Yin Liu and Jun Xu and Ping Wang and Yong-Han Paik and Fanli Meng and Masataka Asagiri and Lynne A. Murray and Alan Frederick Hofmann and Takashi Iida and Christopher K. Glass and David Brenner and Tatiana Kisseleva},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 32},
Hepatic myofibroblasts are activated in response to chronic liver injury of any etiology to produce a fibrous scar. Despite extensive studies, the origin of myofibroblasts in different types of fibrotic liver diseases is unresolved. To identify distinct populations of myofibroblasts and quantify their contribution to hepatic fibrosis of two different etiologies, collagen-α1(I)-GFP mice were subjected to hepatotoxic (carbon tetrachloride; CCl4) or cholestatic (bile duct ligation; BDL) liver… CONTINUE READING
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