Origin of myofibroblasts and cellular events triggering fibrosis.

  title={Origin of myofibroblasts and cellular events triggering fibrosis.},
  author={Matthias Mack and Motoko Yanagita},
  journal={Kidney international},
  volume={87 2},
Renal fibrosis is a major hallmark of chronic kidney disease that is considered to be a common end point of various types of renal disease. To date, the biological meaning of fibrosis during the progression of chronic kidney diseases is unknown and possibly depends on the cell type contributing to extracellular matrix production. During the past decade, the origin of myofibroblasts in the kidney has been intensively investigated. Determining the origins of renal myofibroblasts is important… CONTINUE READING
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