Origin of murine B cell lineages.

  title={Origin of murine B cell lineages.},
  author={Aaron B. Kantor and Leonard A. Herzenberg},
  journal={Annual review of immunology},
Until recently, the hematopoietic stem cells (HSC) that appear early in ontogeny were thought to constitute a homogeneous, self-replenishing population whose developmental potential remains constant throughout the life of the animal. Studies reviewed here, however, demonstrated clear differences in the developmental potential of fetal and adult progenitor populations (including FACS-sorted HSC). These studies, which chart the ability of various progenitor sources to reconstitute functionally… CONTINUE READING
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