Origin of multifocal carcinomas of the bladder and upper urinary tract: Molecular analysis and clinical implications

@article{Habuchi2005OriginOM,
  title={Origin of multifocal carcinomas of the bladder and upper urinary tract: Molecular analysis and clinical implications},
  author={Tomonori Habuchi},
  journal={International Journal of Urology},
  year={2005},
  volume={12}
}
  • T. Habuchi
  • Published 1 August 2005
  • Medicine
  • International Journal of Urology
Abstract 

Molecular characterization of upper urinary tract tumours

To assess gene‐expression patterns of BIRC5, FGFR3, IGF2, KRT20, UPK2, EBF1, CDH1, FXYD3, HTERT, TP53, AGR2, HER2 and VEGF, widely known markers of bladder urothelial carcinoma (UC) in upper tract

Risk stratification for bladder recurrence of upper urinary tract urothelial carcinoma after radical nephroureterectomy

To identify risk factors and develop a model for predicting recurrence of upper urinary tract urothelial carcinoma (UTUC) in the bladder in patients without a history of bladder cancer after radical

Reduce bladder cancer recurrence in patients treated for upper urinary tract urothelial carcinoma_ The REBACARE-trial

A single intravesical instillation of chemotherapy within 10 days following nephro-ureterectomy for urothelial carcinoma of the upper urinary tract has the potential to decrease the risk of a bladder recurrence significantly.

Upper urinary tract urothelial carcinoma and its variants: transition from morphology to personalized molecular characterization in diagnosis, prognosis, and therapy

The aim of this review was to summarize the main morphologic features of UTUC as well as the current status and future role of its molecular characterization in diagnosis, prognosis, and therapy.

The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder

The hypothesis that UCBs following a primary surgically resected UTUC are predominantly clonally derived recurrences and not separate entities is supported.

Development and progression of urothelial carcinoma

Understanding of the mechanisms underlying multifocality and the papillary/nodular morphological relationship is important to determine follow‐up strategies for patients treated for primary urothelial carcinomas and for reconstruction of the urinary tract after cystectomy.

Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity

Improved understanding of molecular features, disease pathogenesis and heterogeneity provides new opportunities for prognostic application, disease monitoring and personalized therapy in urothelial cancer.

Late recurrence in patients with non‐muscle‐invasive bladder cancer after 5‐year cancer‐free periods

  • Y. HirataM. Higuchi N. Shinohara
  • Medicine, Biology
    International journal of urology : official journal of the Japanese Urological Association
  • 2022
This study aimed to elucidate the risk factors for the recurrence in patients with non‐muscle‐invasive bladder cancer who remained cancer free for more than 5 years.

Evidenced‐based clinical practice guideline for upper tract urothelial carcinoma (summary – Japanese Urological Association, 2014 edition)

  • M. OyaE. Kikuchi
  • Medicine
    International journal of urology : official journal of the Japanese Urological Association
  • 2015
A short English version of the original guideline on diagnosis and treatment of upper tract urothelial carcinoma is presented, and its key clinical issues are overviewed.
...

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