Origin of life: The RNA world

  title={Origin of life: The RNA world},
  author={W. Gilbert},
Sur la base de la decouverte d'activites enzymatiques de certains ARN (chez E. coli au cours de la maturation des ARN+ et chez Tetrahymena avec un exon d'un ARNr a auto-epissage), l'auteur postule un systeme, auto-replicatif a l'origine uniquement compose de molecules d'ARN 
On the dimerization of the primitive tRNAs: implications in the origin of genetic code.
A structural model for the first aminoacyl-tRNA synthetase consisting of an RNA complex formed between two primitive tRNA molecules through two intermolecular loop-strand interactions is proposed, with implications in the origin of the genetic code. Expand
A new paradigm for the folding of ribonucleic acids
De recentes decouvertes montrent le role important que joue l’acide ribonucleique (ARN) au sein des cellules, que ce soit le controle de l’expression genetique, la regulation de plusieurs processusExpand
RNA evolution and the origins of life
It is doubtful that life began with RNA, but consideration of what came before RNA must take into account relevant information from geochemistry, prebiotic chemistry and nucleic acid biochemistry. Expand
On the primacy of primordial RNA.
The ability of RNA to catalyze biochemical reactions is used to develop a self-consistent picture of how a primordial RNA could have given rise to the necessary factors and processes of early lifeExpand
RNA catalysis and the origins of life.
  • L. Orgel
  • Biology, Medicine
  • Journal of theoretical biology
  • 1986
The role of RNA catalysis in the origins of life is considered in connection with the discovery of riboszymes, which are RNA molecules that catalyze sequence-specific hydrolysis andExpand
From the RNA world to the RNA/protein world: contribution of some riboswitch-binding species?
Some amino acids and their formal derivatives, currently riboswitch-binding species, could have interacted with polyribonucletides in prebiotic environments, leading to the peptide formation, and would have been an important contribution to the transition from the RNA world to the RNA/Protein world. Expand
Catalytic RNA and the origin of genetic systems.
Why the discovery of catalytic RNA molecules has profound evolutionary implications is outlined, and models for the emergence of metabolic complexity and protein synthesis in a primitive 'RNA world' are discussed, emphasizing the constraints imposed on such models by genetical arguments. Expand
The RNA World as a Model System to Study the Origin of Life
A current view of the biochemistry of the origin of life is presented, focusing on issues surrounding the emergence of an RNA World in which RNA dominated informational and functional roles. Expand
Chemical origins of life: Prebiotic RNA unstuck.
Two separate studies focusing on RNA's backbone connectivity offer partial solutions to some of the problems raised with this hypothesis for the origin of life. Expand
Exiting an RNA world
The RNA world hypothesis gains support from the in vitro evolution of a bifunctional ribozyme that can recognize an activated glutaminyl ester and subsequently aminoacylate a tRNA molecule.


Catalytic activity of an RNA molecule prepared by transcription in vitro.
The RNA moiety M1RNA of ribonuclease P from Escherichia coli and the unprocessed transcript prepared in vitro of the gene for M1 RNA can both perform the cleavage reactions of the canonical enzyme in the absence of the protein moiety. Expand
The intervening sequence RNA of Tetrahymena is an enzyme.
The shortened form of the self-splicing ribosomal RNA intervening sequence of Tetrahymena thermophila acts as an enzyme in vitro that can act as an RNA polymerase, differing from the protein enzyme in that it uses an internal rather than an external template. Expand
Self-splicing RNA: implications for evolution.
  • T. Cech
  • Biology, Medicine
  • International review of cytology
  • 1985
This chapter discusses the evolution of self-splicing RNA and highlights Tetrahymena pre-rRNA splicing is self-catalyzed, which lowers the activation energy for a chemical reaction in which that same molecule is a reactant. Expand
Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena
It is proposed that the IVS portion of the RNA has several enzyme-like properties that enable it to break and reform phosphodiester bonds and that enzymes, small nuclear RNAs and folding of the pre-rRNA into an RNP are unnecessary for these reactions. Expand
The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
The RNA moieties of ribonuclease P purified from both E. coli and B. subtilis can cleave tRNA precursor molecules in buffers containing either 60 mM Mg2+ or 10 mM MG2+ plus 1 mM spermidine, and in vitro, the RNA and protein subunits from one species can complement sub units from the other species in reconstitution experiments. Expand
Biochemistry: Polyribonucleic acids as enzymes
On the origin of RNA splicing and introns