Origin of improved depth penetration in dual-axis optical coherence tomography: a Monte Carlo study.

  title={Origin of improved depth penetration in dual-axis optical coherence tomography: a Monte Carlo study.},
  author={Yang Zhao and Kengyeh K. Chu and Evan T Jelly and Adam Wax},
  journal={Journal of biophotonics},
  volume={12 6},
Recent studies have demonstrated that extended imaging depth can be achieved using dual-axis optical coherence tomography (DA-OCT). By illuminating and collecting at an oblique angle, multiple forward scattered photons from large probing depths are preferentially detected. However, the mechanism behind the enhancement of imaging depth needs further illumination. Here, the signal of a DA-OCT system is studied using a Monte Carlo simulation. We modeled light transport in tissue and recorded the… 


Dual-axis optical coherence tomography for deep tissue imaging.
Dual-axis optical coherence tomography (DA-OCT) is developed which enables deep tissue imaging by using a novel off-axis illumination/detection configuration and shifts the detection priority from multiply scattered to ballistic light.
Signal degradation by multiple scattering in optical coherence tomography of dense tissue: a Monte Carlo study towards optical clearing of biotissues.
It is found that the OCT imaging resolution is almost reduced exponentially with the increase of the probing depth as opposed to the claimed system resolution, demonstrating that optical clearing could be a useful tool to improve the imaging resolution when the light progressively penetrates the high scattering medium.
In vivo ultrahigh-resolution optical coherence tomography.
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Imaging beyond the ballistic limit in coherence imaging using multiply scattered light
By incorporating angle-resolved detection, coherence imaging with multiply scattered photons is shown to be both feasible and potentially superior to existing techniques for performing time-resolving measurements of scattered light.
Improved rejection of multiply scattered photons in confocal microscopy using dual-axes architecture.
It is shown that the dual-axes (DA) confocal architecture has superior rejection of multiply scattered photons in tissue to that of single axis, and thus is sensitive to ballistic photons from deeper within tissue, features that are particularly useful for performing vertical cross-sectional reflectance images in tissue.
Deep tissue imaging using spectroscopic analysis of multiply scattered light
Scattering limits the penetration depth of most optical imaging techniques. Efforts to overcome this limitation often require complex optical or computational schemes. We have developed a new method
Efficient rejection of scattered light enables deep optical sectioning in turbid media with low-numerical-aperture optics in a dual-axis confocal architecture.
The results demonstrate efficient rejection of scattered light in a dual-axis confocal microscope, which enables deep optical sectioning in tissue with subcellular resolution that can distinguish between normal and premalignant pathologies.
Dual-axis confocal microscope for high-resolution in vivo imaging.
We describe a novel confocal microscope that uses separate low-numerical-aperture objectives with the illumination and collection axes crossed at angle theta from the midline. This architecture
Optimizing the performance of dual-axis confocal microscopes via Monte-Carlo scattering simulations and diffraction theory
The contrast and resolution of these designs are evaluated by Monte-Carlo scattering simulations and diffraction theory calculations, respectively and can be used for guiding the optimal designs of DAC-PS and DAC-LS microscopes.
Monte Carlo simulation of an optical coherence tomography signal in homogeneous turbid media.
  • G. Yao, L. Wang
  • Medicine, Physics
    Physics in medicine and biology
  • 1999
The Monte Carlo technique with angle biasing is used to simulate the optical coherence tomography (OCT) signal from homogeneous turbid media and the effect of the optical properties of the medium on the Class I signal decay is studied.