Origin of genes.

  title={Origin of genes.},
  author={Walter Gilbert and Sandro J de Souza and Manyuan Long},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 15},
We discuss two tests of the hypothesis that the first genes were assembled from exons. The hypothesis of exon shuffling in the progenote predicts that intron phases will be correlated so that exons will be an integer number of codons and predicts that the exons will be correlated with compact regions of polypeptide chain. These predictions have been tested on ancient conserved proteins (proteins without introns in prokaryotes but with introns in eukaryotes) and hold with high statistical… CONTINUE READING
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