Origin of dendritic cells in peripheral lymphoid organs of mice

@article{Liu2007OriginOD,
  title={Origin of dendritic cells in peripheral lymphoid organs of mice},
  author={Kang Liu and Claudia Waskow and Xiangtao Liu and Kai-hui Yao and Josephine Hoh and Michel C. Nussenzweig},
  journal={Nature Immunology},
  year={2007},
  volume={8},
  pages={578-583}
}
Parabiosis experiments demonstrating that dendritic cells (DCs) do not equilibrate between mice even after prolonged joining by parabiosis have suggested that DCs are derived from self-renewing progenitors that divide in situ. However, here we found that unequal exchange of DCs between mice joined by parabiosis reflected uneven distribution of DC precursors in blood due to their short half-life in circulation. DCs underwent only a limited number of divisions in the spleen or lymph nodes over a… 

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    Methods in molecular biology
  • 2010
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References

SHOWING 1-10 OF 54 REFERENCES
Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells
TLDR
These differentiated DCs secreted nitric oxide, which mediated the suppression of T cell proliferation in response to antigen presentation by mature DCs, and were identified as an important mechanism by which the microenvironment regulates immune responses.
Development of CD8α-Positive Dendritic Cells from a Common Myeloid Progenitor
TLDR
It is shown that both CD8alpha+ and CD8 alpha- DCs can arise from clonogenic common myeloid progenitors in both thymus and spleen, and phenotypic and functional differences among DC subsets are likely to reflect maturation status rather than ontogeny.
Anatomical Origin of Dendritic Cells Determines Their Life Span in Peripheral Lymph Nodes
TLDR
It is demonstrated that peripheral lymph nodes contain at least four major, functionally separable, and independently derived, DC subsets, which can be clearly demarcated by their CD11c, CD40, and CD8 expression pattern.
In Situ Replication of Immediate Dendritic Cell (DC) Precursors Contributes to Conventional DC Homeostasis in Lymphoid Tissue1
TLDR
It is shown that mouse CD11c+ MHC class II−lineage− cells are immediate precursors of conventional DC and are widely distributed in both bone marrow and lymphoid tissues and highlight the importance of in situ replication of immediate DCp and DC in maintaining conventional DC populations.
Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking.
TLDR
Monocytes cultured with endothelium differentiated into dendritic cells within 2 days, particularly after phagocytosing particles in subendothelial collagen, and migrated across the endot Helium in the ablumenal-to-lumenal direction, as would occur during entry into lymphatics.
Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells.
TLDR
It is concluded that LT alpha 1 bet a2 acts on DCs or DC precursors to promote DC homeostasis, and it is suggested that DC proliferation is an important pathway for locally maintaining these cells in the steady state.
Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo
TLDR
An antigen delivery system targeting these specialized antigen presenting cells in vivo using a monoclonal antibody to a DC-restricted endocytic receptor is devised, which concludes that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness.
Langerhans cells arise from monocytes in vivo
TLDR
It is established that CSF-1 receptor–deficient hematopoietic precursors failed to reconstitute the LC pool in inflamed skin and monocytes with high expression of the monocyte marker Gr-1 were specifically recruited to the inflamedskin, proliferated locally and differentiated into LCs.
Monocytes give rise to mucosal, but not splenic, conventional dendritic cells
TLDR
It is shown that MDPs are in vivo precursors of BM and blood monocytes, and grafted monocytes give rise to DCs in the intestinal lamina propria and lung, but not to conventional CD11chigh DCS in the spleen, which develop during homeostasis from M DPs without a monocytic intermediate.
Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo.
TLDR
A substantial minority of inflammatory monocytes carry phagocytosed particles to lymph nodes and differentiate into DCs, and this transport was reduced by more than 85% in monocyte-deficient osteopetrotic mice.
...
1
2
3
4
5
...