Origin of complexity in hemoglobin evolution

@article{Pillai2020OriginOC,
  title={Origin of complexity in hemoglobin evolution},
  author={Arvind S. Pillai and Shane A. Chandler and Yong Liu and Anthony V. Signore and Carlos R. Cortez-Romero and Justin L. P. Benesch and Arthur Laganowsky and Jay F. Storz and Georg K. A. Hochberg and Joseph W. Thornton},
  journal={Nature},
  year={2020},
  volume={581},
  pages={480 - 485}
}
Most proteins associate into multimeric complexes with specific architectures 1 , 2 , which often have functional properties such as cooperative ligand binding or allosteric regulation 3 . No detailed knowledge is available about how any multimer and its functions arose during evolution. Here we use ancestral protein reconstruction and biophysical assays to elucidate the origins of vertebrate haemoglobin, a heterotetramer of paralogous α- and β-subunits that mediates respiratory oxygen… Expand
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