Origin of broad polydispersion in functionalized dendrimers and its effects on cancer-cell binding affinity.


Nanoparticles with multiple ligands have been proposed for use in nanomedicine. The multiple targeting ligands on each nanoparticle can bind to several locations on a cell surface facilitating both drug targeting and uptake. Experiments show that the distribution of conjugated ligands is unexpectedly broad, and the desorption rate appears to depend… (More)
DOI: 10.1103/PhysRevE.82.036108


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