Origin of aldosterone in trypsin-stimulated rat adrenal zona glomerulosa incubations.

  title={Origin of aldosterone in trypsin-stimulated rat adrenal zona glomerulosa incubations.},
  author={G. Vinson and S. Laird and J. Hinson and R. Teja},
  journal={The Journal of endocrinology},
  volume={135 1},
  • G. Vinson, S. Laird, +1 author R. Teja
  • Published 1992
  • Biology, Medicine
  • The Journal of endocrinology
  • The time-course for the in-vitro secretion of aldosterone and 18-hydroxycorticosterone (18-OH-B) by rat adrenal whole capsular tissue (largely zona glomerulosa) was studied under control and stimulated conditions. The stimulatory effect of trypsin was relatively delayed, and the steroids were significantly enhanced only after 1 h, in contrast to the actions of ACTH, which produced effects after 15 or 30 min. Tissue-sequestered 18-hydroxydeoxycorticosterone (t-18-OH-DOC), which is not affected… CONTINUE READING
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