Origin of a T cell clone with a mismatched combination of MHC restriction and coreceptor expression.

@article{Suzuki1994OriginOA,
  title={Origin of a T cell clone with a mismatched combination of MHC restriction and coreceptor expression.},
  author={Hoshibumi Suzuki and Koji Eshima and Yohtaroh Takagaki and Shigeru Hanaoka and Motoya Katsuki and Minehiko Yokoyama and Tomoko Hasegawa and Sayuri Yamazaki and Nobukata Shinohara},
  journal={Journal of immunology},
  year={1994},
  volume={153 10},
  pages={4496-507}
}
Although the existence of a large number of CD8+ class II MHC-specific CTLs had long been noticed, the origin of such T cells with a discordant combination of specificity and phenotype has been a mystery in the positive selection model. Recent reports suggesting the independency of the positive selection of T cells from coreceptor-mediated signals raised a possibility that they might be the progeny of putative transitional, mismatched, single-positive cells appearing before positive selection… CONTINUE READING